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Research is needed to determine whether the use of e-cigarettes by nonsmoking adolescents could function as a gateway to combustible cigarette use. The team also called for more research into the health effects of e-cigarettes themselves

They found that men with a history of regular cigarette smoking have a considerably higher death rate than men who have never smoked: 63% higher from all causes, 82% higher from heart disease, 106% higher from all cancers, and 200% higher from lung cancer

That is the standard this guide is built around

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